ANXA2 and Werner syndrome: Indeed, several genes belonging to cluster c5 (such as P2RX4, ATP2B1, ANXA6, ATP2A3, SLC8A1, ANXA2, ATP2A2, and SLC24A2) participate in calcium ion transport, indicating the possible release of calcium at the origin of muscle calcium-dependent proteolysis and tissue degeneration41, which has been reported in WS and WB muscles.