Looking at the mechanisms of the effect of vitamin D on PMS and the observed effects of its administration on inflammation and oxidative stress biomarkers which are mediated through Apo-lipoprotein gene expression, parathyroid hormone suppression, repressing NF-kB activation and upregulation of antioxidant systems19,20, it is postulated that improving vitamin D status may improve the inflammatory factors and antioxidant capacity and, hence, decrease the incidence and severity of PMS symptoms. This evidence concerns the gene NFKB1 and premenstrual tension.