For example, in a study where the homer domain of SHANK3 was abolished (exon 21), the KO mice showed anxiogenic behavior in the DL test but not in the EPM and OF40, while in studies where the ankyrin domain was abolished (exons 4–9), there was no observed anxiety-like behavior when tested in the EPM and DL tests41,42. This evidence concerns the gene SHANK3 and Anxiety.