PPARGC1A and cardiac arrhythmia: In this study, the heart dSir2-RNAi flies were exercise trained and we found exercise training also reduced lipid accumulation, enhanced heart function, activated NAD+/dSIR2/PGC-1α pathway, and reduced the risk of arrhythmia, which improved lipotoxic cardiomyopathy induced by heart dSir2 RNAi.