Building on these emerging principles, a study of acute myeloid leukemia (AML) patients treated with IL-2 immunotherapy revealed patients with -21 M HLA-B alleles had significantly better leukemia-free and overall survival compared to patients that were homozygous for -21 T HLA-B alleles and found correlations with diminished expression of HLA-E on primary AML blasts [80]. The gene discussed is IL2; the disease is acute myeloid leukemia.