Therefore, we suggest that in Bhi tumors, TIL-Bs might recruit CD8+ T cells via CXCL9 and crucially contribute to the survival of the CD8+ T cells in the tumor microenvironment due to the in situ secondary costimulation employing CD40L/CD40 and TNFR/TNF superfamily signaling pathways. The gene discussed is CD40; the disease is neoplasm.