Therefore, to assess whether the interactions between CD20+ B cells and CD8+ T cells might be important for the HPV-specific T cell response in HPV-driven tumors, we correlated the presence and density of B cell/CD8+ T cell interactions in the FFPE tumor sections with the proportions of HPV16 E6/E7-specific CD8+ T cells detected in TILs expanded from matched native HPV-positive OPSCC samples (Cohort 2). The gene discussed is MS4A1; the disease is neoplasm.