The multivariate Cox proportional hazard model indicated extranodal extension (p = 0.004, HR = 5.25, 95% CI = 1.68–16.38), high abundance of CD20+ B cells in tumor nests (p = 0.044, HR = 0.97, 95% CI = 0.93–0.99) and high abundance of stromal B cell/CD8+ T cell interactions (p = 0.019, HR = 0.10, 95% CI = 0.02–0.69) as independent prognostic factors (Additional file 2: Table S2). The gene discussed is MS4A1; the disease is neoplasm.