CD8A and neoplasm: Moreover, the proportion of HPV16 E6/E7-specific CD8+ T cells was significantly positively correlated with the density of B cell/CD8+ T cell interactions in the tumor nests (Fig. 3b), indicating that patients with low levels of direct B cell – CD8+ T cell interactions also had low levels of HPV16 E6/E7-specific CD8+ T cells.