TLR2 and Peri-Implantitis: To elucidate the precise mechanism of the suppression of peri-implantitis by mangiferin, further experiments are required, for instance, detecting the expression of different TLR and MAPK members in peri-implant tissues after mangiferin administration and examining the effects of mangiferin on this disease using TLR2 or other TLR gene knockout animal models.