Clinical studies have demonstrated the positive correlation between IL6 and peri-implantitis: higher IL6 expression was observed in diseased sites in patients with peri-implantitis, compared to healthy individuals [36]; and IL6 concentration was reduced in peri-implant sulcus fluid in patients with attenuated peri-implantitis and clinically stable treatment outcomes [37]. Here, IL6 is linked to Peri-Implantitis.