In clear cell renal cell carcinoma, AR suppressed circHIAT1 expression by regulating the expression of its host gene (HIAT1) at the transcriptional level, which resulted in deregulation of miR-195-5p/29a-3p/29c-3p, and increased CDC42 to enhance cell migration and invasion [41]. The gene discussed is CDC42; the disease is clear cell renal carcinoma.