Similar to PI3 and CX3CR1, FYN, DUSP6, POLB and SLC3A2, PILRA, SRPK2 and RNF1 were confirmed to be related to the pathogenesis of ARDS, including inflammation or immunity, endothelial–epithelial barrier, and coagulation function [33–36]. Here, RING1 is linked to acute respiratory distress syndrome.