These were the UK Prospective Diabetes Study (UKPDS), [11] STOP-NIDDM, [3] the Alpha-glucosidase-inhibitor Blocks Cardiac Events in Patients with Myocardial Infarction and Impaired Glucose Tolerance (ABC) trial, [12] and the ACE trial [5] (Table 1). This evidence concerns the gene GAA and type 2 diabetes mellitus.