Because the activity of both MYC and the WNT pathway are profoundly involved in colon cancer [8, 15], we examined the 41 pairs of normal/tumor colonic tissues deposited in the TCGA database for the expression of LEF1 and other genes upregulated by MYC in our RNA-seq dataset (Fig. 1a). Here, MYC is linked to malignant colon neoplasm.