Regulation of ACAD9 and PPARδ by LEF1 underscores the importance of future studies to identify the global signature of genes regulated by LEF1 and potentially other TCF factors in normal and MYC-dependent colonic cells to define the molecular crosstalk between MYC and the WNT pathway in colon cancer. The gene discussed is HNF4A; the disease is malignant colon neoplasm.