Importantly, most of WNT pathway genes induced by MYC, including DVL1, LEF1, RUVBL1, and RUVBL2, were also upregulated in tumor tissues when compared with the normal tissues from the same patients (Fig. 2a and Additional file 2: Figure S2A), suggesting that these genes may play a major role in colon cancer cells. This evidence concerns the gene LEF1 and malignant colon neoplasm.