Talazoparib demonstrated critical antileukemic efficacy as a single-agent and in combination with decitabine in several MDS/CMML and AML cell samples, which might be mediated by the formation of cytotoxic PARP1-DNA complexes [27], DNMT1-DNA complexes [38], and PARP1-DNMT1-DNA complexes [28], respectively. The gene discussed is PARP1; the disease is acute myeloid leukemia.