IGF2 and colorectal carcinoma: Cheng et al. have shown a significant correlation between IGF2 LOI and DMR hypomethylation of IGF2 and H19 but that there was no correlation between marked IGF2 elevation and IGF2 or H19 hypomethylation [140], whereas Tian et al. showed that, in primary CRC, IGF2 LOI is associated with hypomethylation of the six CTCF-binding sites in the IGF2/H19 DMR.