IGF2 and cancer: Among others, it was proven that consumption of ≥15 g alcohol/day was associated with exclusively elevated risk of CRC with IGF2 DMR0 hypomethylation but not risk of cancer with high-level IGF2 DMR0 methylation, suggesting a possible mechanistic link between alcohol intake and CRC risk through IGF2 DMR0 hypomethylation during colorectal carcinogenesis [71].