The next group in terms of incidence (~13–16% of sporadic CRC) is characterized by hypermutations and shows microsatellite instability (MSI) caused by faulty DNA mismatch repair (MMR), which is usually connected to wild-type TP53 and chromosomal instability of a near-diploid pattern (reviewed in Reference [7]). Here, TP53 is linked to colorectal carcinoma.