Coon et al. have demonstrated that while methyl prednisolone enhances the expression of ASBT in rabbits, in the rabbit model of IBD, glucocorticoids appear to reverse the inhibition of ASBT by likely inhibiting the immune inflammatory mediator responsible for the ASBT inhibition and not by directly enhancing the transcription of ASBT as was the case in normal rabbits [16]. The gene discussed is SLC10A2; the disease is inflammatory bowel disease.