CTLA4 and colorectal carcinoma: While the role of immunosurveillance in the control of CRC growth and progression is assumed to be of great importance [17,18], patients appear to be resistant to the blockade of immunological checkpoints with monoclonal antibodies (mAbs) specific for cytotoxic T lymphocyte-associated protein 4 (CTLA4), programmed cell death 1 (PDCD1, best known as PD-1) and the PD-1 ligand CD274 (best known as PD-L1), with the exception of a minority of subjects characterized by microsatellite instability (MSI) lesions [20,21].