Interestingly, the exposure of immune cells to visceral adipocyte conditioned media from obese and CRC affected subjects favors IL-10 production, reduces the immunostimulatory activity of DC and hampers their capacity to generate γδ T cell-mediated responses induced ex vivo, further highlighting the existence of a regulatory/suppressive AT microenvironment in both obesity and CRC [34]. Here, IL10 is linked to colorectal carcinoma.