When samples were divided into only three groups (normal mucosa, adenoma and CRC), a correlation of the severity of the disease was observed with the expression of a higher number of miRNAs and their target genes, namely miR-200b (rs = −0.620, p < 0.001), miR-200c (rs = −0.401, p < 0.001), miR-141 (rs = −0.420, p < 0.001), miR-429 (rs = −0.522, p < 0.001), and CDKN1B (rs = 0.377, p = 0.007), PTPN13 (rs = −0.426, p = 0.006), and RND3 (rs = 0.467, p = 0.016). The gene discussed is CDKN1B; the disease is adenoma.