However, amyloid β plaques and tau neurofibrillary tangles, the hallmark pathologies of Alzheimer’s dementia, are also observed and correlate with cognitive status in patients with PDD [33]; thus, future longitudinal follow-up studies concomitantly incorporating an assessment of pS129-α-synuclein, α-synuclein, amyloid β protein, and total and phospho-tau in plasma to predict the risk of PDD are needed. Here, MAPT is linked to Alzheimer disease.