PROM1 and melanoma: The contribution of CD133 to the invasiveness and metastasis of melanoma cells was validated by CD133 depletion by CD133 siRNA, as well by CRISPR-Cas9 knockdown of CD133 in BAK-R cells, both of which inhibited invasion, while metastasis was also inhibited using CD133 CRISPR-Cas9 knockdown.