MDM2 and cancer: FGF2 [32,33] and CHEK4 [34] are up-regulated while the expression of CHEK1 [35,36], WT1 [37], MDM2 [38,39,40,41], BARD1 [42,43,44], BMP2 [45], BAMBI [46], and SOD2 [47,48,49], have been reported to be down-regulated in several cancer subtypes, including CRC.