Although, it is intriguing to note that PGC-1α and mitochondrial mass/function are known to decrease with age [65,66,67,68,69,70,71], and combined with the drop in estrogen during menopause, this may explain why the incidence of NAFLD and NASH in women approaches (and may surpass) that of men after menopause [7,72]. The gene discussed is PPARGC1A; the disease is metabolic dysfunction-associated steatohepatitis.