Mitochondrial ROS (mtROS) and lipid peroxidation also trigger proinflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), interleukin 1 beta (IL-1β), which are critical mediators of inflammation in NASH [47,48,49,50]. This evidence concerns the gene IL1B and metabolic dysfunction-associated steatohepatitis.