In line with increased liver PGC-1α being beneficial in NAFLD, liver-specific overexpression of PGC-1α in Sprague Dawley male rats increases fatty acid oxidation and tricarboxylic acid (TCA) cycle activity in isolated liver mitochondria, and this was coupled with reduced hepatic and plasma triglycerides [73]. The gene discussed is PPARGC1A; the disease is metabolic dysfunction-associated steatotic liver disease.