Genomic interrogation for biomarkers of tumor radiosensitivity and normal tissue toxicity such as the CD73/adenosine pathway might well be suited to gain new mechanistic insight into tissue-specific roles of specific immune cell types from the innate and adaptive immune system, and disease-promoting aspects of the multifaceted cross-talk between damaged resident cells, extracellular matrix molecules, soluble mediators and infiltrating immune cells including tissue-specific activation of signaling pathways in the irradiated tissue environment. Here, NT5E is linked to neoplasm.