For example, the data obtained so far suggest that ADORA2B may play a more important pathogenic role than ADORA2A in the pathogenesis of radiation-induced pulmonary fibrosis, BLM-induced pulmonary fibrosis, idiopathic pulmonary fibrosis and chronic kidney disease, whereas ADORA2A seems to be a major player in radiation- and BLM-induced dermal fibrosis. Here, ADORA2B is linked to chronic kidney disease.