KLRK1 and neoplasm: A second approach was to exploit DAP12, a signaling adaptor molecule involved in signal transduction of activating NK cell receptors, fused to the anti-prostate stem cell Ag (PSCA) scFv(AM1) to confer improved cytotoxicity to the NK cell line, YTS, against PSCA-positive tumor cells [264], or fused to the extracellular domain of NKG2D itself [265].