Accordingly, our in vitro and in vivo results indicate that OR-LoVo cells are resistant to OXA as a result of increasing the expression of miR-31-5p, which decreases the expression of LATS2 and its downstream proteins p21 and p27, induces cell proliferation, causing the tumor to become malignant, and leads to lung metastasis. The gene discussed is LATS2; the disease is neoplasm.