GAST and familial pancreatic carcinoma: Numerous findings from in vitro studies on various pancreatic cancer cell lines, in vivo animal studies, and studies of human pancreatic cancers, support the conclusion that gastrin stimulation may play an important role in human pancreatic ductal adenocarcinoma growth (PDAC), invasion, and pathogenesis [78,82,90,221,255,270,271,272,273].