Mg active transport in the GI tract is regulated by TRPM cation channels 6 and 7 and they are up regulated by activation of colonic H+K+ATPase, and it is proposed that PPIs inhibition of colonic H+K+ATPase results in decreased TRPM activity, causing hypomagnesemia in some patients [319,320,322]. This evidence concerns the gene ATP12A and Hypomagnesemia.