In other studies, glycine–extended gastrin (Gly-Gastrin) is reported to have proliferative effects on the colonic mucosa in mice overexpressing Gly-Gastrin; and similar effects are seen in transgenic mice over-expressing progastrin, which in the latter case, in the presence of p53 mutations, CRC is seen [254,255]. The gene discussed is GAST; the disease is colorectal carcinoma.