Therefore, activation of PPARGC1A and NFE2L2 in the post-treated group of idiopathic infertile men indicates that ‘FH PRO for Men’ modulates the expression of proteins involved in the antioxidant defense mechanism and has a beneficial effect at the subcellular level to counteract and protect the spermatozoa from oxidative stress. Here, PPARGC1A is linked to Infertility.