The expression of S100A8/A9 seems to be tissue and cell specific which is differentially increased in various abnormal conditions such as: Inflammatory Bowel Disease (IBD), Rheumatoid Arthritis (RA), Cystic Fibrosis (CF), different types of cancers and neurodegenerative disorders [15, 16]. The gene discussed is S100A8; the disease is cystic fibrosis.