Variants of this member of the solute carrier gene family have been associated with a number of cardiovascular disease phenotypes related to hypertension [86], congestive heart failure [87], obesity [88], heart rate [89], and electrocardiographic QT interval [90], as have some polymorphisms of the CRP gene [17,91–93]. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.