Consistent with other studies, there are 19 SNPs within a 43 Kb span on chr 12 encompassing the HNF1A gene, a hepatic transcription factor which has been repeatedly found to affect CRP expression [24,77], as well as C12orf43, variants of which have been linked to cardiovascular disease [103] and CRP expression [20]. Here, C12orf43 is linked to cardiovascular disorder.