Variants in BNC2 (basonuclin 2), a highly conserved protein belonging to the C2H2 zinc finger proteins, have been associated with scoliosis is Japanese [40] and Chinese people.[41] A locus with the nearest candidate gene SEMA6D, an encoding member of the semaphorin family of cell surface or soluble proteins that regulate cell to cell interactions, was associated with tibial diaphyseal width and is expressed in osteoclasts.[42] FRZB (frizzled B related protein) is a major component of the WNT signaling pathway and is integral to chondrocyte development.[43]. This evidence concerns the gene ZNF146 and scoliosis.