Of note, presumably because of the deletion of 1 Nfkbiz allele, the disease onset of the K14-IL17Aind Ctrl mice occurred later than in K14-IL17Aind mice harboring 2 Nfkbiz wild-type alleles (data not shown), which already have full-blown psoriasis at week 6 (18). This evidence concerns the gene NFKBIZ and psoriasis.