We found that, upon IL-36 stimulation, IκBζ was actively recruited to the promoter regions of its target genes, including genes encoding for the chemokines Csf3, Cxcl1, and Cxcl2 and the psoriasis-associated antimicrobial proteins Defb4 and S100a9 (Figure 4G). Here, NFKBIZ is linked to psoriasis.