Interestingly, it has recently been revealed that expression of IκBζ, encoded by NFKBIZ, is upregulated in psoriatic lesions, while global IκBζ deficiency in mice completely protects against imiquimod-mediated (IMQ-mediated) or IL-36α–mediated psoriasis (7, 8). This evidence concerns the gene NFKBIZ and psoriasis.