The typical cardiovascular diseases (CVDs) includes heart attack (or myocardial infarction), atherosclerosis, heart failure and stroke.57 In clinical, key biomarkers for dyslipidaemia and high blood pressure include TC, TG, HDL, LDL, VCAM, ICAM, Apo‐A and Apo‐B.58 ROCK pathway is another signalling pathway related to CVDs, the blocking of which leads to cardiovascular protection through decreasing NADPH oxidases and ROS level. Here, APOB is linked to myocardial infarction.