The Angpt-TEK pathway is essential for SC development and maintenance, and loss of function mutations in TEK or the gene encoding its primary ligand ANGPT1 have been identified in patients with primary congenital glaucoma, a severe form of glaucoma characterized by early/childhood onset, buphthalmos and optic neuropathy (Souma et al., 2016; Thomson et al., 2017; Kabra et al., 2017). This evidence concerns the gene TEK and Optic neuropathy.