Given that Mboat7 knockdown promoted striking hepatic steatosis (Figure 2E), and the fact that adipose tissue expression of Mboat7 is negatively correlated with insulin sensitivity across strains of the HMDP (Figure 1F) we examined glucose homeostasis in Mboat7 ASO-treated mice fed a high fat diet (Figure 5). Here, INS is linked to Hepatic steatosis.