INS and obesity due to melanocortin 4 receptor deficiency: Given the fact that obesity is commonly associated with insulin resistance and type 2 diabetes mellitus (Cohen et al., 2011; Machado and Diehl, 2016; Rinella and Sanyal, 2016; Younossi et al., 2018), we also examined the relationship between Mboat7 expression and insulin sensitivity in the HMDP.