PNPLA3 and fatty liver disease: It is interesting to note that the well-known PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets, and similarly reorganizes the lipidome and proteome to promote liver disease progression (BasuRay et al., 2019; Wang et al., 2019; Mitsche et al., 2018; BasuRay et al., 2017).