Functionally, enforced expression of circ‐GRB10 suppressed NP cell apoptosis whereas knockdown of circ‐GRB10 produced the opposite the effect, suggesting that the aberrant downregulation of circ‐GRB10 in NP tissues might contribute to IDD through impairing NP cell survival. Here, GRB10 is linked to intervertebral disk degenerative disorder.