IL1B and intervertebral disk degenerative disorder: Cheng et al45 showed that miR‐200c was overexpressed in human IDD NP samples and inducible by TNF‐α plus IL‐1β in cultured NP cells where enforced expression of miR‐200c promoted apoptosis and shifted ECM homeostasis from anabolism towards catabolism (ie reduced aggrecan and collagen II but enhanced ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)‐4, ADAMTS‐5, MMP‐13 and MMP‐3 expression).