In this regard, circVMA21 (circRNA Vacuolar ATPase Assembly Factor VMA21) was found to be downregulated in IDD NP tissues, where it served as a sponge for miR‐200c and restrained apoptosis and ECM anabolism/catabolism imbalance induced by TNF‐α and IL‐1β. The gene discussed is IL1B; the disease is intervertebral disk degenerative disorder.