Current studies have been reported that multiple factors, including Notch1 and miR‐29a, mediated by HBX could activate AKT,50, 51 and maybe these factors but not CSF1‐R mediated by IL‐34 played a dominant role on the activation of AKT in HBX‐positive HCC cells. This evidence concerns the gene NOTCH1 and hepatocellular carcinoma.