RAC1 and persistent truncus arteriosus: Expressions of mRNAs for the p22phox and gp91phox membrane components and for the p47phox, p67phox, Rac1 cytosolic components of NADPH oxidase in LV of TAC mice were increased compared with those of sham mice, which were in turn all downregulated with the treatment of APN (Fig. 4c–g).