This study aimed to test the hypothesis that NGAL concentrations in CSF would be higher in steroid-responsive meningitis-arteriitis (SMRA) and MUO (Meningoencephalitis of unknown origin) than in non-inflammatory (idiopathic epilepsy, intracranial neoplasia, intervertebral disc disease) CNS disease and neurological healthy dogs. The gene discussed is LCN2; the disease is meningoencephalitis.