MAPT and Alzheimer disease: The major neuropathological AD hallmarks involve proteinous aggregates found in the form of intracellular NFTs, containing hyperphosphorylated tau (Holtzman et al., 2011; Uddin et al., 2019c), and extracellular senile plaques, containing Aβ deposits of heterogeneous lengths (Selkoe, 1998; Uddin et al., 2018c).