Overall, the clinical manifestations of IgE-mediated CMPA comprise cutaneous symptoms (70–75%: urticaria, generalized maculopapular rashes, flushing, and angioedema), gastrointestinal symptoms (13–34%: nausea, vomiting, colicky abdominal pain, and diarrhea), respiratory problems (1–8%: nasal pruritus and congestion, rhinorrhea, sneezing, wheezing, dyspnea, chest tightness, and symptoms of asthma and allergic rhinitis), alterations that affect more than one organ system (26%), and severe and potentially life-threatening anaphylaxis (1–4%) (Table 1) (17, 50). This evidence concerns the gene IGHE and urticaria.