Overall, the intervention strategies in CMPA have been targeted at three levels: (1) primary prevention of initial IgE sensitization; (2) secondary prevention of the triggering of allergic reactions to interrupt the development of food allergy in IgE-sensitized children; and (3) tertiary prevention to reduce the manifestation of end-organ allergic disease in children with established food allergy via avoidance of allergenic food and induction of tolerance (i.e., baked milk products, formulas, and oral immunotherapy) (6, 45). Here, IGHE is linked to food allergy.