I. Systemic IgE-mediated reactions (Anaphylaxis) A. Immediate-onset reactions B. Late-onset reactions II. IgE-mediated gastrointestinal reactions A Oral allergy syndrome B Immediate gastrointestinal allergy III gE-mediated respiratory reactions A Asthma and rhinitis secondary to ingestion of milk B Asthma and rhinitis secondary to inhalation of milk (e.g., occupational asthma) IV IgE-mediated cutaneous reactions A Immediate-onset reactions 1 Acute urticaria or angioedema 2 Contact urticarial B Late-onset reactions   Atopic dermatitis. This evidence concerns the gene IGHE and angioedema.