SNHG12 and osteosarcoma: In addition, SNHG12 expression in different osteosarcoma cell lines was found to be up-regulated by ~6.2-fold in 143B cells, up to ~3.9-fold in MG63 cells, ~5.4-fold in MG63/DXR cells, and up to ~5.6-fold in U2OS cells compared to normal human osteoblast cell lines (11, 29) (Table 1).