Furthermore, altered expression of miR-218 was found to be associated with increased tumorigenesis by increasing the epithelial-to-mesenchymal transition in NSCLC by targeting Matrix Metallopeptidase 9 (MMP-9), Vimentin, Slug, Zinc Finger E-Box Binding Homeobox 2 (ZEB2), and E-cadherin proteins (Figure 2) (32). This evidence concerns the gene ZEB2 and non-small cell lung carcinoma.