To test this idea, we examined the effect of culture medium on the polyamine uptake activity using human colorectal carcinoma cell line HCT116 stably transfected with the expression vector containing caveolin-1-encoding cDNA in the antisense orientation (HCT116/Cav-1 AS) and empty vector transfected cells (HCT116/Mock). This evidence concerns the gene CAV1 and colorectal carcinoma.