A correlation between polymorphisms or aberrant expressions of XRCC4, XRCC5 (encoding Ku80), XRCC6 (encoding Ku70), ARTEMIS, and LIG4 (encoding DNA ligase 4) genes and risk of MM development has been reported (Roddam et al., 2002; Hayden et al., 2007; Roddam et al., 2010). This evidence concerns the gene XRCC5 and Miyoshi myopathy.