Although significant efficacy of anti-TNF has been reported, side effects of TNF-α inhibition such as infection (Lim et al., 2018), malignant tumor (Wang et al., 2016), autoimmune disease (Perez-De-Lis et al., 2017), and demyelinating disease (Gill et al., 2017) have been reported. The gene discussed is TNF; the disease is demyelinating disease.