For instance, we have previously shown that the HTLV-1 protein Tax, implicated in driving oncogenesis and subsequent development of ATLL (Baratella et al., 2017; Billman et al., 2017; Tagaya and Gallo, 2017; Mahgoub et al., 2018), may be found in EVs from infected cells (Jaworski et al., 2014a). The gene discussed is CNTN2; the disease is adult T-cell leukemia/lymphoma.