A role of active AKT and/or ERK1/2 in cardiac protection but also generation of arrhythmias has been reported by others before (Cheng et al., 2016;Ezeani and Elom, 2017; Hu et al., 2019) and underscores a putative role of these pathways in our model system. The gene discussed is MAPK3; the disease is cardiac arrhythmia.