CRYAB and neurodegenerative disease: Multiple reports demonstrate HspB1 and HspB5 upregulation in neurodegenerative disease (Renkawek et al., 1999; Dabir et al., 2004; Schwarz et al., 2010; Brownell et al., 2012; Liu et al., 2015; Leyns and Holtzman, 2017).