HSPB1 and Alzheimer disease: For example, in the AD brain, along with other tauopathies including PSP, CBD, and FTDP-17, HspB1 and HspB5 are upregulated in reactive glial cells and can be found to colocalized with glial tau inclusions (Wilhelmus et al., 2006c; Björkdahl et al., 2008; Schwarz et al., 2010).