MCODE was used to identify the major hubs of QLQX against CHF, which generated a well-organized cluster containing 17 nodes (SLC22A8, SLCO1B3, QLQX-9, QLQX-11, QLQX-5, QLQX-8, CYP1A1, QLQX-12, QLQX-6, ATP1A1, VEGFA, CYP2B6, STAT3, SLCO1A2, QLQX-10, QLQX-4, and STAT4). The gene discussed is STAT4; the disease is congestive heart failure.