Thus, QLQX can rectify the injury of microvascular endothelial cells induced by Hcy while significantly decreasing the levels of IL-6, p-JAK2, and p-STAT3, which suggests that QLQX may inhibit inflammatory processes and promote angiogenesis in CHF via the JAK/STAT signaling pathway. This evidence concerns the gene JAK2 and congestive heart failure.