This is in line with data showing that an increase in isoforms containing exon 10 leads to the formation of abnormal tau filaments in patients with tauopathies (Spillantini et al., 1998) and that carriers of the MAPT H2 haplotype, which express more tau containing exons 2/3 than H1 carriers, appear to be more protected from neurodegeneration (Caffrey et al., 2008). The gene discussed is MAPT; the disease is tauopathy.