In this context it is interesting to note that tau phosphorylated at the moderately conserved threonine residue 181 (pThr181) is an established core biomarker for AD (Vanmechelen et al., 2000), which shows a significant increase in phosphorylation in the CSF of patients with AD compared to controls (Russell et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.