VIPR2 and Parkinson disease: As Treg function has been shown to be deficient in both PD patients and in mice immunized with α-Syn, and since LBT-3627 augments Treg activity with subsequent neuroprotection (Reynolds et al., 2010; Saunders et al., 2012; Olson et al., 2015), we assessed the effects of VIPR2 activation on Treg numbers and function in the context of α-Syn overexpression.