CRH and Anxiety: Overexpression of CRH has repeatedly been shown to induce stress-like behavioral responses including increased fear and anxiety under baseline conditions (Stenzel-Poore et al., 1994; Van Gaalen et al., 2002; Lu et al., 2008; Kolber et al., 2010; Dedic et al., 2012; Flandreau et al., 2012).