CRH and major depressive disorder: To assess whether deletion of Crh from GABAergic forebrain neurons would alter stress susceptibility, CrhCKO–GABA mice were subjected to 3 weeks of CSDS, a paradigm commonly applied to induce anxiety- and depression-related endophenotypes in mice (Berton et al., 2006; Golden et al., 2011; Gassen et al., 2014; Hartmann et al., 2016; Dedic et al., 2018b).