Accordingly, dysregulation of the CRH/CRHR1 system has been observed in stress-related psychopathologies including depression and anxiety disorders (Laryea et al., 2012; Deussing, 2013; Janssen and Kozicz, 2013; Henckens et al., 2016; Dedic et al., 2017). This evidence concerns the gene CRHR1 and depressive disorder.