DNM1L and Parkinson disease: SUMO-2/3 for instance has been shown to inhibit Drp1-Mff interaction preventing mitochondrial fragmentation, however, SUMO-1 stabilizes Drp1 leading to enhanced fragmentation; with evidence establishing a link between SUMO and PD, this further implicates mitochondrial dynamics in the pathogenesis of the disease (Guo et al., 2013, 2017; Fu et al., 2014; Vijayakumaran et al., 2015; Henley et al., 2018; Vijayakumaran and Pountney, 2018).