PRKN and Parkinson disease: Interestingly, mutations in PINK1 and Parkin genes cause autosomal recessive forms of familial early onset PD (Valente et al., 2001; Mata et al., 2004; Kumar et al., 2017), implicating a role of mitophagy in the aetiopathogenesis of PD (Dawson and Dawson, 2010).